Pigmented Villonodular Synovitis (PVNS) is a benign (non-cancerous) condition that occurs due to overgrowth of the synovium, the tissues that line the joints, or production of excess synovial fluid. A majority of PVNS cases occur in the knee. Treatment of PVNS commonly includes a synovectomy to remove the excess tissue and fluid.

A neurofibroma is a somewhat rare, benign (non-cancerous) soft-tissue tumor that can occur on any peripheral nerve. It presents as a small mass with mild to no symptoms. Surgical removal is a common treatment for nuerofibromas.

A schwannoma is a benign (non-cancerous), soft-tissue mass that presents on the outer, protective layer of a nerve, called the epineurium. To treat, a schwannoma can be marginally excised, meaning only the schwannoma is surgically removed, to spare or protect the nerve from excision.

Infantile Fibromatosis is a rare condition that involves the growth of a single or numerous benign (non-cancerous) tumors. It is often referred to as myofibromatosis, due to the abundance of fibrous and smooth muscle stoma. Infantile fibromatosis can affect the skin, muscles, soft-tissues, bones and rarely visceral organs.

Giant Cell Tumor (GCT) of Tendon Sheath is a benign, or non-cancerous, tumor that can emerge from the tendon sheath or synovium. It most commonly affects the fingers and hand and can be treated with surgical resection or removal of the mass.

Undifferentiated Pleomorphic Sarcoma (UPS) is a cancerous (malignant) soft-tissue tumor that most commonly affects the soft-tissues of the upper and lower extremities, however can occur anywhere.